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Article

Polk mutant mice have a spontaneous mutator phenotype.

DNA repair - 3 Dec 2009

Stancel J Nicole Kosarek, McDaniel Lisa D, Velasco Susana, Richardson James, Guo Caixia, Friedberg Errol C

Abstract excerpt

Mice defective for the Polk gene, which encodes DNA polymerase kappa, are viable and do not manifest obvious phenotypes. The present studies document a spontaneous mutator phenotype in Polk(-/-) mice. The initial indication of enhanced spontaneous mutations in these mice came from the serendipitous observation of a postulated founder mutation that manifested in multiple disease states among a cohort of mice...

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Identifiers

PMID: 19783230
DOI: 10.1016/j.dnarep.2009.09.003
PMCID: PMC2787749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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