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Article

Subfertility and growth restriction in a new galactose-1 phosphate uridylyltransferase (GALT) - deficient mouse model.

European journal of human genetics : EJHG - 1 Oct 2014

Tang Manshu, Siddiqi Anwer, Witt Benjamin, Yuzyuk Tatiana, Johnson Britt, Fraser Nisa, Chen Wyman, Rascon Rafael, Yin Xue, Goli Harish, Bodamer Olaf A, Lai Kent

Abstract excerpt

The first GalT gene knockout (KO) mouse model for Classic Galactosemia (OMIM 230400) accumulated some galactose and its metabolites upon galactose challenge, but was seemingly fertile and symptom free. Here we constructed a new GalT gene-trapped mouse model by injecting GalT gene-trapped mouse embryonic stem cells into blastocysts, which were later implanted into pseudo-pregnant females. High percentage GalT...

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Source

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Identifiers

PMID: 24549051
DOI: 10.1038/ejhg.2014.12
PMCID: PMC4169538

Genes

GALT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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