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Article

A germ-line <i>Tsc1</i> mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by <i>Tsc2</i> mutation in mice

3 Jul 2001

Abstract excerpt

Tuberous sclerosis (TS) is characterized by the development of hamartomas in various organs and is caused by a germ-line mutation in either TSC1 or TSC2 tumor suppressor genes. From the symptomatic resemblance among TS patients, involvement of TSC1 and TSC2 products in a common pathway has been suggested. Here, to analyze the function of the Tsc1 product, we established a line of Tsc1 (TSC1 homologue) knockout...

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Identifiers

PMID: 11438694
DOI: 10.1073/pnas.151033798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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