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Article

Salt inducible kinases 2 and 3 are required for thymic T cell development.

Scientific reports - 3 Nov 2021

Nefla Meriam, Darling Nicola J, van Gijsel Bonnello Manuel, Cohen Philip, Arthur J Simon C

Abstract excerpt

Salt Inducible Kinases (SIKs), of which there are 3 isoforms, are established to play roles in innate immunity, metabolic control and neuronal function, but their role in adaptive immunity is unknown. To address this gap, we used a combination of SIK knockout and kinase-inactive knock-in mice. The combined loss of SIK1 and SIK2 activity did not block T cell development. Conditional knockout of SIK3 in...

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Identifiers

PMID: 34732767
DOI: 10.1038/s41598-021-00986-0
PMCID: PMC8566462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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