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Article

Pathophysiology of genetic deficiency in tissue kallikrein activity in mouse and man.

Thrombosis and haemostasis - 1 Sept 2013

Waeckel L, Potier L, Richer C, Roussel R, Bouby N, Alhenc-Gelas F

Abstract excerpt

Study of mice rendered deficient in tissue kallikrein (TK) by gene inactivation and human subjects partially deficient in TK activity as consequence of an active site mutation has allowed recognising the physiological role of TK and its peptide products kinins in arterial function and in vasodilatation, in both species. TK appears as the major kinin forming enzyme in arteries, heart and kidney. Non-kinin mediated...

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PMID: 23572029
DOI: 10.1160/TH12-12-0937

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ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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