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Genetics of Mefloquine Resistance in the Rodent Malaria Parasite Plasmodium chabaudi

23 Jan 2003

Abstract excerpt

The genetic determinants of resistance to mefloquine in malaria parasites are unclear. Some studies have implied that amplification of, or mutations in, the multidrug resistance gene pfmdr1 in Plasmodium falciparum may be involved. Using the rodent malaria model Plasmodium chabaudi, we investigated the role of the orthologue of this gene, pcmdr1, in a stable mefloquine-resistant mutant, AS(15MF/3), selected from...

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PMID: 12543682
DOI: 10.1128/aac.47.2.709-718.2003

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