Article
Multiple drug resistance genes in malaria -- from epistasis to epidemiology.
Molecular microbiology - 1 Aug 2005
Duraisingh Manoj T, Refour Philippe
Abstract excerpt
A decline in our ability to successfully treat patients with malaria infections of the parasitic protozoan Plasmodium falciparum with cheap quinoline drugs has led to a huge escalation in morbidity and mortality in recent years. Many approaches have been taken, including classical genetics, reverse genetics and molecular epidemiology, to identify the molecular determinants underlying this resistance. The...
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