Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sulfadoxine-pyrimethamine resistance in the rodent malaria parasite Plasmodium chabaudi.

Antimicrobial agents and chemotherapy - 1 Aug 2002

Hayton Karen, Ranford-Cartwright Lisa C, Walliker David

Abstract excerpt

We have studied resistance to sulfadoxine-pyrimethamine (S/P) in the rodent malaria parasite Plasmodium chabaudi. A stable S/P-resistant mutant, AS(50S/P), was selected by drug treatment of a clone, AS(PYR), already resistant to pyrimethamine. The sequences of the P. chabaudi dhfr and dhps genes were obtained and found to be identical in AS(50S/P) and AS(PYR), showing that resistance to S/P in AS(50S/P) was not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dihydropteroate Synthase
Share to Drug Combinations
Share to Genes, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muridae

Share to Plasmodium chabaudi

Share to Pyrimethamine

Share to Sulfadoxine

Share to Tetrahydrofolate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 12121922
DOI: 10.1128/AAC.46.8.2482-2489.2002
PMCID: PMC127344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sulfadoxine-pyrimethamine resistance in the rodent malaria parasite Plasmodium chabaudi.PMID 12121922Read ↗

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?Semantic proximity Read ↗

Low-dose treatment with sulfadoxine-pyrimethamine combinations selects for drug-resistant Plasmodium falciparum strains.Semantic proximity Read ↗

Chromosomal rearrangements and point mutations in the DHFR-TS gene of Plasmodium chabaudi under antifolate selection.Semantic proximity Read ↗

Fitness of sulfadoxine-resistant Plasmodium berghei harboring a single mutation in dihydropteroate synthase (DHPS).Semantic proximity Read ↗

Genetics of Mefloquine Resistance in the Rodent Malaria Parasite Plasmodium chabaudiSemantic proximity Read ↗

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model.Semantic proximity Read ↗

Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax.Semantic proximity Read ↗

Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru.Semantic proximity Read ↗

Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.Semantic proximity Read ↗

High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei.Semantic proximity Read ↗

Pyrimethamine resistant mutations in Plasmodium falciparum.Semantic proximity Read ↗

Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.