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Article

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum.

ACS infectious diseases - 9 Apr 2021

Rocamora Frances, Gupta Purva, Istvan Eva S, Luth Madeline R, Carpenter Emma F, Kümpornsin Krittikorn, Sasaki Erika, Calla Jaeson, Mittal Nimisha, Carolino Krypton, Owen Edward, Llinás Manuel, Ottilie Sabine, Goldberg Daniel E, Lee Marcus C S, Winzeler Elizabeth A

Abstract excerpt

In malaria, chemical genetics is a powerful method for assigning function to uncharacterized genes. MMV085203 and GNF-Pf-3600 are two structurally related napthoquinone phenotypic screening hits that kill both blood- and sexual-stage P. falciparum parasites in the low nanomolar to low micromolar range. In order to understand their mechanism of action, parasites from two different genetic backgrounds were exposed...

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Identifiers

PMID: 33715347
DOI: 10.1021/acsinfecdis.0c00676
PMCID: PMC8042660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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