Genetic analysis of mefloquine-resistant mechanism of Plasmodium falciparum.

doi:10.1093/nass/48.1.163

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Article

Genetic analysis of mefloquine-resistant mechanism of Plasmodium falciparum.

Nucleic acids symposium series (2004) - 1 Jan 2004

Nishiyama Yuko, Okuda Yohei, Kim Hye-Sook, Huruta Takahisa, Kimura Mikio, Wataya Yusuke

Abstract excerpt

We studied DNA sequence polymorphism, expression level of pfmdr1 gene and sensitivity of major antimalarial drugs in both mefloquine sensitive and resistant strains to elucidate mechanism of mefloquine resistance. Mefloquine-resistant 523a R/24 strain exhibited decreased susceptibility to mefloqu...

Topics

Alleles
Animals
Antimalarials
Drug Resistance
Gene Expression Regulation
Mefloquine
Multidrug Resistance-Associated Proteins
Plasmodium falciparum
RNA, Messenger

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