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Article

Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factor

10 Apr 2017

Abstract excerpt

Platelet-derived growth factor (PDGF) is one of the major mitogens and chemoattractants for mesenchymal and glial cells. Nowadays, the expression of PDGFs are recognized widely in our body, and emerging data indicate the relevance of PDGFs in the homeostatic control of systemic connective tissue as well as parenchymal cells such as neurons. Aberrant PDGF signal is primarily tumorigenic, and also regulates tumor...

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PMID: 28393435
DOI: 10.1111/pin.12530

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