Article
Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice.
Nature genetics - 1 May 1997
Jenuth J P, Peterson A C, Shoubridge E A
Abstract excerpt
Mammalian mitochondrial DNA (mtDNA) is a highly polymorphic, high-copy-number genome that is maternally inherited. New mutations in mtDNA segregate rapidly in the female germline due to a genetic bottleneck in early oogenesis and as a result most individuals are homoplasmic for a single species of mtDNA. Sequence variants thus accumulate along maternal lineages without genetic recombination. Most of the extant...
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