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Article

Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation.

The Journal of cell biology - 6 Jul 2020

Chen Zhe, Wang Zong-Heng, Zhang Guofeng, Bleck Christopher K E, Chung Dillon J, Madison Grey P, Lindberg Eric, Combs Christian, Balaban Robert S, Xu Hong

Abstract excerpt

Although mitochondrial DNA (mtDNA) is prone to accumulate mutations and lacks conventional DNA repair mechanisms, deleterious mutations are exceedingly rare. How the transmission of detrimental mtDNA mutations is restricted through the maternal lineage is debated. Here, we demonstrate that mitochondrial fission, together with the lack of mtDNA replication, segregate mtDNA into individual organelles in the...

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Identifiers

PMID: 32375181
DOI: 10.1083/jcb.201905160
PMCID: PMC7337505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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