Article
Mitochondrial genotype segregation and the bottleneck.
Reproductive biomedicine online - 1 Jan 2000
Smith Lawrence C, Bordignon Vilceu, Couto Marcia M, Garcia Sheila M, Yamazaki Walt, Meirelles Flávio V
Abstract excerpt
Mitochondria can produce a wide range of effects on many physiological systems, and these effects and their severity can vary with the ratio of mutant and wild-type mitochondrial genotype, i.e. heteroplasmy. It is therefore critical to understand the biological mechanisms controlling the segregation of mitochondrial genes, not only in somatic tissue, but also in the germ cell lineage, since the latter is the...
Topics
- Animals
- Cell Nucleus
- Chromosome Segregation
- DNA, Mitochondrial
- Embryo, Mammalian
- Female
- Genetics, Population
- Genotype
- Germ Cells
- Humans
- Mice
- Mitochondria