Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.

Nature genetics - 1 Feb 2008

Cree Lynsey M, Samuels David C, de Sousa Lopes Susana Chuva, Rajasimha Harsha Karur, Wonnapinij Passorn, Mann Jeffrey R, Dahl Hans-Henrik M, Chinnery Patrick F

Abstract excerpt

Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but the mechanisms involved are not fully understood. Females harboring a mixture of mutant and wild-type mtDNA (heteroplasmy) transmit a varying proportion of mutant mtDNA to their offspring. In humans with mtDNA disorders, the proportion of mutated mtDNA inherited from the mother correlates with disease severity. Rapid changes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Blastomeres

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Embryo Transfer

Share to Embryonic Development

Share to Mice, Inbred C3H

Share to Mice, Inbred CBA

Share to Microinjections

Source

Identifiers

PMID: 18223651
DOI: 10.1038/ng.2007.63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.PMID 18223651Read ↗

Mitochondrial DNA segregation in the developing embryo.Semantic proximity Read ↗

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.Semantic proximity Read ↗

Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro.Semantic proximity Read ↗

Mitochondrial genotype segregation and the bottleneck.Semantic proximity Read ↗

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of MiceSemantic proximity Read ↗

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.Semantic proximity Read ↗

Keeping mtDNA in shape between generations.Semantic proximity Read ↗

Mitochondrial genotype segregation and effects during mammalian development: applications to biotechnology.Semantic proximity Read ↗

Transmission of the human mitochondrial genome.Semantic proximity Read ↗

Modulating mitochondrial DNA mutations: factors shaping heteroplasmy in the germ line and somatic cells.Semantic proximity Read ↗

Mitochondrial genotype segregation in a mouse heteroplasmic lineage produced by embryonic karyoplast transplantation.Semantic proximity Read ↗

Influence of Maternal Aging on Mitochondrial Heterogeneity, Inheritance, and Function in Oocytes and Preimplantation EmbryosSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.