Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitigation of age-dependent accumulation of defective mitochondrial genomes.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2022

Tsai Pei-I, Korotkevich Ekaterina, O'Farrell Patrick H

Abstract excerpt

Unknown processes promote the accumulation of mitochondrial DNA (mtDNA) mutations during aging. Accumulation of defective mitochondrial genomes is thought to promote the progression of heteroplasmic mitochondrial diseases and degenerative changes with natural aging. We used a heteroplasmic Drosophila model to test 1) whether purifying selection acts to limit the abundance of deleterious mutations during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Disease Models, Animal
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Genome, Mitochondrial

Share to Mitochondrial Diseases

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 35881807
DOI: 10.1073/pnas.2119009119
PMCID: PMC9351377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitigation of age-dependent accumulation of defective mitochondrial genomes.PMID 35881807Read ↗

Mitigation of the age-dependent decline in mitochondrial genome integritySemantic proximity Read ↗

A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations.Semantic proximity Read ↗

Mitochondrial curation for the next generation.Semantic proximity Read ↗

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.Semantic proximity Read ↗

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs <i>in vivo</i>Semantic proximity Read ↗

Modulating mitochondrial DNA mutations: factors shaping heteroplasmy in the germ line and somatic cells.Semantic proximity Read ↗

Avoiding Extinction: Recent Advances in Understanding Mechanisms of Mitochondrial DNA Purifying Selection in the Germline.Semantic proximity Read ↗

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo.Semantic proximity Read ↗

Selection promotes age-dependent degeneration of the mitochondrial genomeSemantic proximity Read ↗

Mitochondria, maternal inheritance, and male aging.Semantic proximity Read ↗

Maternal age enhances purifying selection on pathogenic mutations in complex I genes of mammalian mtDNA.Semantic proximity Read ↗

Mitochondria, maternal inheritance, and asymmetric fitness: why males die younger.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.