Mitochondrial DNA segregation in the developing embryo.

doi:10.1093/humrep/15.suppl_2.229

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Article

Mitochondrial DNA segregation in the developing embryo.

Human reproduction (Oxford, England) - 1 Jul 2000

Shoubridge E A

Abstract excerpt

Mitochondrial (mt)DNA is strictly maternally inherited in mammals; new mutations thus segregate along maternal lineages without the benefit of homologous recombination with mtDNA of paternal origin. Despite the high mtDNA copy number (approximately 100000 or more) in mature oocytes, and despite the relatively small number of cell divisions during oogenesis, mtDNA sequence variants segregate rapidly between...

Topics

Chromosome Segregation
DNA, Mitochondrial
Embryo, Mammalian
Embryonic and Fetal Development
Extrachromosomal Inheritance
Genetic Counseling
Genetic Variation
Humans
Mitochondria
Mitochondrial Myopathies
Oogenesis
Preimplantation Diagnosis
Prenatal Diagnosis

Source

Open in PubMed

Identifiers

PMID: 11041528
DOI: 10.1093/humrep/15.suppl_2.229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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