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Article

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.

The Journal of cell biology - 20 Jan 2003

Trapani Joseph A, Sutton Vivien R, Thia Kevin Y T, Li Yu Qin, Froelich Christopher J, Jans David A, Sandrin Mauro S, Browne Kylie A

Abstract excerpt

The 280-kD cation-independent mannose-6-phosphate receptor (MPR) has been shown to play a role in endocytic uptake of granzyme B, since target cells overexpressing MPR have an increased sensitivity to granzyme B-mediated apoptosis. On this basis, it has been proposed that cells lacking MPR are poor targets for cytotoxic lymphocytes that mediate allograft rejection or tumor immune surveillance. In the present...

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Identifiers

PMID: 12538642
DOI: 10.1083/jcb.200210150
PMCID: PMC2172645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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