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Article

Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008

Kurschus Florian C, Fellows Edward, Stegmann Elisabeth, Jenne Dieter E

Abstract excerpt

How granzymes gain entry into the cytosol of target cells during killer cell attack has been the subject of several studies in the past, but the effective delivery mechanism during target cell encounter has not been clarified. Here we show that granzyme B (GzmB) mutants lacking binding to negatively charged, essentially heparan-sulfate-containing membrane receptors are poorly endocytosed yet are delivered to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18772390
DOI: 10.1073/pnas.0801724105
PMCID: PMC2544534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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