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Article

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.

Immunity - 18 Jul 2017

Yoon Seongmin, Kovalenko Andrew, Bogdanov Konstantin, Wallach David

Abstract excerpt

Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell death in which rupture of cellular membranes yields release of intracellular components. We report that MLKL also associated with endosomes and controlled the transport of endocytosed proteins, thereby enhancing degradation of receptors and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28666573
DOI: 10.1016/j.immuni.2017.06.001

Genes

MLKL
RIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.PMID 28666573Read ↗

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Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.Semantic proximity Read ↗

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.Semantic proximity Read ↗

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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.Semantic proximity Read ↗

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitisSemantic proximity Read ↗

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The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced ApoptosisSemantic proximity Read ↗

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes NecroptosisSemantic proximity Read ↗

The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.Semantic proximity Read ↗

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