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A Method for Detecting Intracellular Perforin in Mouse Lymphocytes

28 Oct 2014

Abstract excerpt

Cytotoxic lymphocytes destroy pathogen-infected and transformed cells through the cytotoxic granule exocytosis death pathway, which is dependent on the delivery of proapoptotic granzymes into the target cell cytosol by the pore-forming protein, perforin. Despite the importance of mouse models in understanding the role of cytotoxic lymphocytes in immune-mediated disease and their role in cancer immune...

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PMID: 25348626
DOI: 10.4049/jimmunol.1402207

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