Article
Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway.
Molecular cell - 1 Mar 2001
Lamaze C, Dujeancourt A, Baba T, Lo C G, Benmerah A, Dautry-Varsat A
Abstract excerpt
Clathrin-dependent endocytosis has long been presented as the only efficient mechanism by which transmembrane receptors are internalized. We selectively blocked this process using dominant-negative mutants of Eps15 and showed that clathrin-mediated endocytosis of transferrin was inhibited, while endocytosis of interleukin 2 (IL2) receptors proceeded normally. Ultrastructural and biochemical experiments showed...
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