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Article

The molecular basis for perforin oligomerization and transmembrane pore assembly.

Immunity - 1 May 2009

Baran Katherine, Dunstone Michelle, Chia Jenny, Ciccone Annette, Browne Kylie A, Clarke Christopher J P, Lukoyanova Natalya, Saibil Helen, Whisstock James C, Voskoboinik Ilia, Trapani Joseph A

Abstract excerpt

Perforin, a pore-forming protein secreted by cytotoxic lymphocytes, is indispensable for destroying virus-infected cells and for maintaining immune homeostasis. Perforin polymerizes into transmembrane channels that inflict osmotic stress and facilitate target cell uptake of proapoptotic granzymes...

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Identifiers

PMID: 19446473
DOI: 10.1016/j.immuni.2009.03.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19446473-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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