Article
Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.
The EMBO journal - 1 Aug 1994
Ludwig T, Munier-Lehmann H, Bauer U, Hollinshead M, Ovitt C, Lobel P, Hoflack B
Abstract excerpt
In higher eukaryotes, the transport of soluble lysosomal enzymes involves the recognition of their mannose 6-phosphate signal by two receptors: the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor (CI-MPR) and the cation-dependent mannose 6-phosphate receptor (CD-MPR). It is not known why these two different proteins are present in most cell types. To investigate their relative...
Topics
- Animals
- Cathepsin D
- Cells, Cultured
- Endocytosis
- Female
- Fibroblasts
- Genotype
- Glucuronidase
- Lectins, C-Type
- Lysosomes
- Male
- Mannose Receptor