Article
The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits.
The Journal of cell biology - 1 Apr 1992
Pelchen-Matthews A, Boulet I, Littman D R, Fagard R, Marsh M
Abstract excerpt
The lymphocyte glycoprotein CD4 is constitutively internalized and recycled in nonlymphoid cells, but is excluded from the endocytic pathway in lymphocytic cells (Pelchen-Matthews, A., J. E. Armes, G. Griffiths, and M. Marsh. 1991. J. Exp. Med. 173: 575-587). Inhibition of CD4 endocytosis is dependent on CD4 expressing an intact cytoplasmic domain and is only observed in cells where CD4 can interact with the...
Topics
- 3T3 Cells
- Animals
- CD4 Antigens
- Cell Line
- Coated Pits, Cell-Membrane
- Endocytosis
- HeLa Cells
- Humans
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Mice
- Mutation