Article
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.
British journal of clinical pharmacology - 1 Jan 2003
Sachse Christoph, Bhambra Upinder, Smith Gillian, Lightfoot Tracy J, Barrett Jennifer H, Scollay Jenna, Garner R Colin, Boobis Alan R, Wolf C Roland, Gooderham Nigel J
Abstract excerpt
AIMS: Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described. METHODS: From genomic DNA, 114 British Caucasians (49 colorectal cancer cases and 65 controls) were genotyped for the CYP1A2 polymorphisms -3858G-->A (allele CYP1A2*1C), -2464T-->delT (CYP1A2*1D),...
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