Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP1A2 F21L and F186L polymorphisms in an Italian population sample.

Drug metabolism and pharmacokinetics - 1 Jun 2007

Pucci Laura, Geppetti Annalisa, Maggini Valentina, Lucchesi Daniela, Maria Rossi Anna, Longo Vincenzo

Abstract excerpt

P450 cytochromes (CYPs) enzymes play a major role in variability of drug response and cancer susceptibility. In particular, up to 60-fold interindividual variation has been detected in the activity of CYP1A2, which is involved in the metabolism of caffeine, several drugs and various toxic and carcinogenic compounds. Aim of this study is to assess the frequency of CYP1A2 F21L and F186L polymorphisms (formerly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Italy
Share to Amino Acid Substitution
Share to Cytochrome P-450 CYP1A2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genotype

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 17603224
DOI: 10.2133/dmpk.22.220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP1A2 F21L and F186L polymorphisms in an Italian population sample.PMID 17603224Read ↗

The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis.Semantic proximity Read ↗

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.Semantic proximity Read ↗

Variability of caffeine metabolism by CYP1A2 polymorphism in different populationsSemantic proximity Read ↗

Human cytochrome P4501A2.Semantic proximity Read ↗

Allele frequency of CYP2C19 in a Portuguese population.Semantic proximity Read ↗

CYP3A4 and MDR1 alleles in a Portuguese population.Semantic proximity Read ↗

The importance of CYP1A2 genetic polymorphism in relation to coffee intake and high blood pressure in the Romanian populationSemantic proximity Read ↗

Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms.Semantic proximity Read ↗

CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer.Semantic proximity Read ↗

Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism.Semantic proximity Read ↗

Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population.Semantic proximity Read ↗

The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.