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Article

Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms.

Pharmacogenomics - 1 May 2008

Gunes Arzu, Dahl Marja-Liisa

Abstract excerpt

CYP1A2 is involved in the metabolism of several widely used drugs and endogenous compounds, and in the activation of procarcinogens. Both genetic and environmental factors influence the activity of this enzyme. The current knowledge regarding factors influencing the activity of CYP1A2 is summarized in this review. Substrates, inhibitors and inducers of CYP1A2 activity, as well as phenotyping probes, are...

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PMID: 18466106
DOI: 10.2217/14622416.9.5.625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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