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Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.

Environmental and molecular mutagenesis - 1 Mar 2013

Gervasini Guillermo, Ghotbi Roza, Aklillu Eleni, San Jose Carmen, Cabanillas Agustin, Kishikawa Junko, Benitez Julio, Carrillo Juan Antonio

Abstract excerpt

In this study, we analyzed the influence of CYP1A2 genetic variation and enzyme activity on lung cancer risk in a high-incidence area. A total of 95 lung cancer patients and 196 controls were genotyped for the -3860G/A, -3113A/G, -2467T/delT, -739T/G, and -163C/A polymorphisms in the 5'-untranslated region of the gene. In addition, a subset of 70 patients and 115 controls were phenotyped by high-performance...

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PMID: 23138776
DOI: 10.1002/em.21747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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