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Article

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.

Pharmacogenetics and genomics - 1 Aug 2005

Landi Stefano, Gemignani Federica, Moreno Victor, Gioia-Patricola Lydie, Chabrier Amélie, Guino Elisabeth, Navarro Matilde, de Oca Javier, Capellà Gabriel, Canzian Federico

Abstract excerpt

OBJECTIVES: Sporadic colorectal cancer (CRC) is considered a multifactorial disease where multiple exposures interact with the individual genetic background resulting in risk modulation. We performed an association study aimed to investigate the role of single nucleotide polymorphisms (SNPs) within genes of phase I (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP2E1, CYP2C9, CYP2C19, CYP3A4, ADH2, EPHX1) and phase II...

Topics

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Case-Control Studies
Colorectal Neoplasms
Enzymes
GSTM3 gene
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 16006997
DOI: 10.1097/01.fpc.0000165904.48994.3d

Genes

ALDH2
COMT
EPHX1
GSTA2
GSTA4
GSTM1
GSTM3
GSTP1
MTHFR
NAT1
NAT2
NQO1
TPMT

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