The Effect of the CYP1A1*2A Allele on Colorectal Cancer Susceptibility in a British Population.

doi:10.1089/gtmb.2016.0099

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The Effect of the CYP1A1*2A Allele on Colorectal Cancer Susceptibility in a British Population.

Genetic testing and molecular biomarkers - 1 Aug 2016

Öztaş Ezgi, Özhan Gül, Daly Ann K

Abstract excerpt

AIM: Colorectal cancer (CRC) is a major health problem despite recent improvements in overall survival rates. Genetic polymorphisms affecting carcinogen biotransformation or DNA repair play pivotal roles in the carcinogenesis process. CYP1A1*2A (6235 T/C, rs4646903, MspI) is thought to be associated with an increased risk of CRC because of its role in metabolic activation of polycyclic aromatic hydrocarbons;...

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PMID: 27243113
DOI: 10.1089/gtmb.2016.0099

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