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Article

Human cytochrome P4501A2.

IARC scientific publications - 1 Jan 1999

Landi M T, Sinha R, Lang N P, Kadlubar F F

Abstract excerpt

CYP1A2, a member of the cytochrome P450 superfamily (CYPs), is involved in the metabolic activation of several carcinogens, among them aromatic and heterocyclic amines, nitroaromatic compounds, mycotoxins and estrogens. Several drugs are also metabolized by CYP1A2. Individual differences in CYP1A2 activity may thus influence individual susceptibility to cancer risk and the therapeutic efficacy of some drugs. In...

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PMID: 10493258

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