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Article

CYP1A2 and coffee intake and the modifying effect of sex, age, and smoking.

The American journal of clinical nutrition - 1 Jul 2012

Rodenburg Eline M, Eijgelsheim Mark, Geleijnse Johanna M, Amin Najaf, van Duijn Cornelia M, Hofman Albert, Uitterlinden Andre G, Stricker Bruno H, Visser Loes E

Abstract excerpt

BACKGROUND: The enzyme CYP1A2 (cytochrome 1A2) is involved in the metabolism of certain drugs and caffeine, and its activity can be influenced by factors such as sex, age, and smoking. The single nucleotide polymorphism (SNP) rs762551A>C, which has also been studied for its modifying effect on cardiovascular disease, has been reported to alter enzyme activity. OBJECTIVE: The objective was to study the effect of...

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PMID: 22648710
DOI: 10.3945/ajcn.111.027102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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