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Article

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis.

Biology of reproduction - 1 Feb 2003

Weber Philipp, Schuler Michael, Gérard Christelle, Mark Manuel, Metzger Daniel, Chambon Pierre

Abstract excerpt

We have obtained a PrP-Cre-ER(T) transgenic mouse line (28.8) that selectively expresses in testis the tamoxifen-inducible Cre-ER(T) recombinase under the control of a mouse Prion protein (PrP) promoter-containing genomic fragment. Cre-ER(T) is expressed in spermatogonia and spermatocytes, but not in Sertoli and Leydig cells. We also established reporter PrP-L-EGFP-L transgenic mice harboring a LoxP-flanked...

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Identifiers

PMID: 12533419
DOI: 10.1095/biolreprod.102.005801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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