Article
Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre.
Genesis (New York, N.Y. : 2000) - 1 Jun 2007
Gallardo Teresa, Shirley Lane, John George B, Castrillon Diego H
Abstract excerpt
Cell type-specific genetic modification using the Cre/loxP system is a powerful tool for genetic analysis of distinct cell lineages. Because of the exquisite specificity of Vasa expression (confined to the germ cell lineage in invertebrate and vertebrate species), we hypothesized that a Vasa promoter-driven transgenic Cre line would prove useful for the germ cell lineage-specific inactivation of genes. Here we...
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