Controlling gene expression in the urothelium using transgenic mice with inducible bladder specific Cre-lox recombination.

Abstract excerpt

PURPOSE: Clinical advances in bladder cancer would require the development of novel animal model systems closely mimicking human disease. We describe a system of conditional gene targeting using the Cre/loxP system that permits temporally controlled mutation of tumor suppressor genes in bladder urothelium. MATERIALS AND METHODS: Mice expressing Cre-ERT, a fusion between Cre-recombinase and a mutated hormone...

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