Article
Targeted somatic mutagenesis in mouse epidermis.
Hormone research - 1 Jan 2000
Indra A K, Li M, Brocard J, Warot X, Bornert J M, Gérard C, Messaddeq N, Chambon P, Metzger D
Abstract excerpt
Gene targeting in the mouse is a powerful tool to study mammalian gene function. The possibility to efficiently introduce somatic mutations in a given gene, at a chosen time and/or in a given cell type will further improve such studies, and will facilitate the generation of animal models for human diseases. To create targeted somatic mutations in the epidermis, we established transgenic mice expressing the...
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