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Article

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2000

Schmidt E E, Taylor D S, Prigge J R, Barnett S, Capecchi M R

Abstract excerpt

The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-site infidelity in transgenic animals. We produced lines of transgenic mice that use the mouse Protamine 1 (Prm1) gene...

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Identifiers

PMID: 11087830
DOI: 10.1073/pnas.240471297
PMCID: PMC17639

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