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Article

The transmembranous domain of CD40 determines CD40 partitioning into lipid rafts.

FEBS letters - 16 Jan 2003

Bock Jürgen, Gulbins Erich

Abstract excerpt

Stimulation of CD40 has been previously shown to result in a release of ceramide in small sphingolipid-enriched rafts in the cell membrane [Grassmé et al., J. Immunol. 168 (2002) 298-307]. Those rafts fused to larger signaling platforms that served to cluster CD40. Here, we defined molecular mechanisms of CD40 clustering in membrane platforms. To this end, we replaced the transmembranous domain of CD40 with that...

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PMID: 12527381
DOI: 10.1016/s0014-5793(02)03784-5

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