CD40 translocation to lipid rafts: signaling requirements and downstream biological events.

Abstract excerpt

CD40, a member of the TNF receptor family, is expressed on a variety of immune and non-immune cells. Its interaction with its ligand, CD154, plays a pivotal role in humoral and cell-mediated immunity. A low level of CD40 is constitutively associated within membrane lipid rafts and, upon engagement, this level is significantly enhanced. In this study, our objective is to evaluate the process of CD40/lipid raft...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CD40 Antigens
• Share to CD40 Ligand