Article
Signaling through CD43 regulates CD4 T-cell trafficking.
Blood - 15 Oct 2007
Mody Purvi D, Cannon Judy L, Bandukwala Hozefa S, Blaine Kelly M, Schilling Alexander B, Swier Kevin, Sperling Anne I
Abstract excerpt
The mucin-like protein CD43 is excluded from the immune synapse, and regulates T-cell proliferation as well as T-cell migration. While the CD43 cytoplasmic domain is necessary for regulation of T-cell activation and proliferation, the mechanism via which CD43 regulates trafficking is not well defined. To investigate whether CD43 phosphorylation regulates its function in T cells, we used tandem mass spectrometry...
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