Article
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
The Journal of experimental medicine - 1 Jan 1996
Leitenberg D, Novak T J, Farber D, Smith B R, Bottomly K
Abstract excerpt
The CD45 tyrosine phosphatase plays an important role in regulating T lymphocyte activation, but the function of the different isoforms of CD45 is not known. T cell transfectants have been prepared that express individual CD45 isoforms in cells with a well-defined T cell receptor (TCR) from the D...
Topics
- Amino Acid Sequence
- Antigen Presentation
- Base Sequence
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Line
- Flow Cytometry
- Immunologic Capping
- Leukocyte Common Antigens
- Lymphocyte Activation
- Molecular Sequence Data
- Phenotype
- Phosphatidylinositol Diacylglycerol-Lyase