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Article

Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transduction.

The Journal of biological chemistry - 1 Jun 2001

Yang H, Reinherz E L

Abstract excerpt

CD2 mediates T cell adhesion via its ectodomain and signal transduction utilizing its 117-amino acid cytoplasmic tail. Here we show that a significant fraction of human CD2 molecules is inducibly recruited into lipid rafts upon CD2 cross-linking by a specific pair of mitogenic anti-CD2 monoclonal antibodies (anti-T11(2) + anti-T11(3)) or during cellular conjugate formation by CD58, the physiologic ligand...

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Identifiers

PMID: 11376005
DOI: 10.1074/jbc.M009852200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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