Article
A novel mutation in CD40 and its functional characterization.
Human mutation - 1 Jun 2009
Qi Chun-Jian, Zheng Lu, Ma Hong-Bing, Fei Min, Qian Ke-Qing, Shen Bai-Rong, Wu Chang-Ping, Vihinen Mauno, Zhang Xue-Guang
Abstract excerpt
CD40 is a costimulatory protein expressed on the surface of many different cells. It delivers signals regulating diverse cellular responses, including proliferation, differentiation, growth suppression, and cell death. In this study, we report a novel CD40 mutant (c.234C>A or p.H78Q) that is expressed in the U266 cell line and in freshly isolated tumor cells. Three-dimensional structural model and Scatchard...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.