Article
A dominant-negative mutant of the Rab5 GTPase enhances T cell signaling by interfering with TCR down-modulation in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1997
André P, Boretto J, Hueber A O, Régnier-Vigouroux A, Gorvel J P, Ferrier P, Chavrier P
Abstract excerpt
TCR triggering results in the down-modulation of engaged receptors by endocytosis. As a result of this process, Ag-binding sites are depleted from the surface and signaling responses should be attenuated. To test the importance of TCR down-regulation on T cell signaling, we generated mice expressing a dominant-negative form of Rab5 (Rab5N133I) in T cells. Rab5, a monomeric GTPase of the Ras superfamily, has been...
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