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Article

T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering.

Molecular and cellular biology - 1 Jul 2010

Hashimoto-Tane Akiko, Yokosuka Tadashi, Ishihara Chitose, Sakuma Machie, Kobayashi Wakana, Saito Takashi

Abstract excerpt

We studied the function of lipid rafts in generation and signaling of T-cell receptor microclusters (TCR-MCs) and central supramolecular activation clusters (cSMACs) at immunological synapse (IS). It has been suggested that lipid raft accumulation creates a platform for recruitment of signaling molecules upon T-cell activation. However, several lipid raft probes did not accumulate at TCR-MCs or cSMACs even with...

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PMID: 20498282
DOI: 10.1128/MCB.00160-10
PMCID: PMC2897564

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Source receipt: pubmed, retrieved 7 Sept 2026.

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