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Article

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.

Immunology letters - 22 Jan 2003

Blackwell Jenefer M, Searle Susan, Mohamed Hiba, White Jacqueline K

Abstract excerpt

Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages; (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding...

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PMID: 12527228
DOI: 10.1016/s0165-2478(02)00231-6

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