Article
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.
The Journal of experimental medicine - 1 Sept 1995
Vidal S, Tremblay M L, Govoni G, Gauthier S, Sebastiani G, Malo D, Skamene E, Olivier M, Jothy S, Gros P
Abstract excerpt
In mice, natural resistance or susceptibility to infection with intracellular parasites is determined by a locus or group of loci on chromosome 1, designated Bcg, Lsh, and Ity, which controls early microbial replication in reticuloendothelial organs. We have identified by positional cloning a can...
Topics
- Alleles
- Animals
- Carrier Proteins
- Cation Transport Proteins
- Cells, Cultured
- Chimera
- Crosses, Genetic
- Female
- Genes
- Humans
- Immunity, Innate
- Infant, Newborn
- Leishmania donovani
- Leishmaniasis, Visceral