Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.

doi:10.1016/1357-4310(96)88773-9

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Article

Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.

Molecular medicine today - 1 May 1996

Blackwell J M

Abstract excerpt

The ability of macrophages to become activated is central to antimicrobial immunity. Microbial stimuli can elicit a cascade of gene-inductive events mediating inflammation, elimination of the invading organism and induction of T-cell memory against reinvasion. Nramp1, a gene originally identified...

Topics

Animals
Autoimmune Diseases
Carrier Proteins
Cation Transport Proteins
Genetic Predisposition to Disease
Humans
Immunity, Innate
Infections
Macrophages
Membrane Proteins
Mice
Structure-Activity Relationship

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