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Article

Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis.

The Journal of infectious diseases - 15 Dec 2002

Awomoyi Agnes A, Marchant Arnaud, Howson Joanna M M, McAdam Keith P W J, Blackwell Jenefer M, Newport Melanie J

Abstract excerpt

Host genetic factors are major determinants of susceptibility to tuberculosis, and an understanding of the molecular basis of this observation has major implications for the development of novel therapies and vaccines. Slc11a1 (formerly Nramp1), the first murine infection susceptibility locus identified, regulates early innate responses to intracellular pathogens. Variation in the human homologue SLC11A1 is...

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PMID: 12447767
DOI: 10.1086/345920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis.PMID 12447767Read ↗

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